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Activation of the SNF2 Family ATPase ALC1 by Poly(ADP-ribose) in a Stable ALC1·PARP1·Nucleosome Intermediate

The human ALC1/CHD1L oncogene encodes an SNF2 family ATPase with a macrodomain that binds poly(ADP-ribose) (PAR). We and others previously showed that ALC1 possesses a cryptic ATP-dependent nucleosome remodeling activity that is potently activated in the presence of PARP1 and NAD(+), its substrate f...

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Detalhes bibliográficos
Main Authors: Gottschalk, Aaron J., Trivedi, Rushi D., Conaway, Joan W., Conaway, Ronald C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527939/
https://ncbi.nlm.nih.gov/pubmed/23132853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.401141
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