SATB2 induction of a neural crest mesenchyme-like program drives melanoma invasion and drug resistance

Recent genomic and scRNA-seq analyses of melanoma demonstrated a lack of recurrent genetic drivers of metastasis, while identifying common transcriptional states correlating with invasion or drug resistance. To test whether transcriptional adaptation can drive melanoma progression, we made use of a...

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Publicado en:eLife
Autores principales: Fazio, Maurizio, van Rooijen, Ellen, Dang, Michelle, van de Hoek, Glenn, Ablain, Julien, Mito, Jeffrey K, Yang, Song, Thomas, Andrew, Michael, Jonathan, Fabo, Tania, Modhurima, Rodsy, Pessina, Patrizia, Kaufman, Charles K, Zhou, Yi, White, Richard M, Zon, Leonard I
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cancer Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7880683/
https://ncbi.nlm.nih.gov/pubmed/33527896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.64370
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