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A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation
The “cancerized field” concept posits that cells in a given tissue share an oncogenic mutation or insult and are thus cancer-prone, yet only discreet clones within the field initiate tumors. Nearly all benign nevi carry oncogenic BRAF(V600E) mutations, but they only rarely become melanoma. The zebra...
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| 出版年: | Science |
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| 主要な著者: | , , , , , , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4868069/ https://ncbi.nlm.nih.gov/pubmed/26823433 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad2197 |
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