A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation

The “cancerized field” concept posits that cells in a given tissue share an oncogenic mutation or insult and are thus cancer-prone, yet only discreet clones within the field initiate tumors. Nearly all benign nevi carry oncogenic BRAF(V600E) mutations, but they only rarely become melanoma. The zebra...

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Udgivet i:Science
Main Authors: Kaufman, Charles K., Mosimann, Christian, Fan, Zi Peng, Yang, Song, Thomas, Andrew, Ablain, Julien, Tan, Justin L., Fogley, Rachel D., van Rooijen, Ellen, Hagedorn, Elliott, Ciarlo, Christie, White, Richard, Matos, Dominick, Puller, Ann-Christin, Santoriello, Cristina, Liao, Eric, Young, Richard A., Zon, Leonard I.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868069/
https://ncbi.nlm.nih.gov/pubmed/26823433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad2197
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