SATB2 induction of a neural crest mesenchyme-like program drives melanoma invasion and drug resistance

Recent genomic and scRNA-seq analyses of melanoma demonstrated a lack of recurrent genetic drivers of metastasis, while identifying common transcriptional states correlating with invasion or drug resistance. To test whether transcriptional adaptation can drive melanoma progression, we made use of a...

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Библиографические подробности
Опубликовано в: :eLife
Главные авторы: Fazio, Maurizio, van Rooijen, Ellen, Dang, Michelle, van de Hoek, Glenn, Ablain, Julien, Mito, Jeffrey K, Yang, Song, Thomas, Andrew, Michael, Jonathan, Fabo, Tania, Modhurima, Rodsy, Pessina, Patrizia, Kaufman, Charles K, Zhou, Yi, White, Richard M, Zon, Leonard I
Формат: Artigo
Язык:Inglês
Опубликовано: eLife Sciences Publications, Ltd 2021
Предметы:
Cancer Biology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7880683/
https://ncbi.nlm.nih.gov/pubmed/33527896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.64370
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