SATB2 induction of a neural crest mesenchyme-like program drives melanoma invasion and drug resistance

Recent genomic and scRNA-seq analyses of melanoma demonstrated a lack of recurrent genetic drivers of metastasis, while identifying common transcriptional states correlating with invasion or drug resistance. To test whether transcriptional adaptation can drive melanoma progression, we made use of a...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Fazio, Maurizio, van Rooijen, Ellen, Dang, Michelle, van de Hoek, Glenn, Ablain, Julien, Mito, Jeffrey K, Yang, Song, Thomas, Andrew, Michael, Jonathan, Fabo, Tania, Modhurima, Rodsy, Pessina, Patrizia, Kaufman, Charles K, Zhou, Yi, White, Richard M, Zon, Leonard I
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2021
Assuntos:
Cancer Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7880683/
https://ncbi.nlm.nih.gov/pubmed/33527896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.64370
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