Neural crest state activation in NRAS driven melanoma, but not in NRAS-driven melanocyte expansion

NRAS mutations are frequently found in many deadly malignancies and are the second most common oncogene driving malignant melanoma. Here, we generate a rapid transient transgenic zebrafish model of NRAS(Q61R)-mutant melanoma. These fish develop extensive melanocytic proliferation in approximately 4...

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Bibliographic Details
Published in:Dev Biol
Main Authors: McConnell, Alicia M., Mito, Jeffrey K., Ablain, Julien, Dang, Michelle, Formichella, Luke, Fisher, David E., Zon, Leonard I.
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6281797/
https://ncbi.nlm.nih.gov/pubmed/29883661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2018.05.026
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