GAB2 induces tumor angiogenesis in NRAS-driven melanoma

GAB2 is a scaffold protein with diverse upstream and downstream effectors. MAPK and PI3K signaling pathways are known effectors of GAB2. It is amplified and overexpressed in a variety of human tumors including melanoma. Here we show a previously undescribed role for GAB2 in NRAS-driven melanoma. Spe...

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Detalhes bibliográficos
Main Authors: Yang, Ying, Wu, Julia, Demir, Ahu, Castillo-Martin, Mireia, Melamed, Rachel D., Zhang, Gao, Fukunaga-Kanabis, Mizuho, Perez-Lorenzo, Rolando, Zheng, Bin, Silvers, David N., Brunner, Georg, Wang, Shuang, Rabadan, Raul, Cordon-Cardo, Carlos, Celebi, Julide Tok
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3813964/
https://ncbi.nlm.nih.gov/pubmed/22926523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.367
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