Targeting critical kinases and anti-apoptotic molecules overcomes steroid resistance in MLL-rearranged leukaemia

BACKGROUND: Acute lymphoblastic leukaemia with mixed lineage leukaemia gene rearrangement (MLL-ALL) frequently affects infants and is associated with a poor prognosis. Primary refractory and relapsed disease due to resistance to glucocorticoids (GCs) remains a substantial hurdle to improving clinica...

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Gepubliceerd in:EBioMedicine
Hoofdauteurs: de Groot, Anne P., Saito, Yoriko, Kawakami, Eiryo, Hashimoto, Mari, Aoki, Yuki, Ono, Rintaro, Ogahara, Ikuko, Fujiki, Saera, Kaneko, Akiko, Sato, Kaori, Kajita, Hiroshi, Watanabe, Takashi, Takagi, Masatoshi, Tomizawa, Daisuke, Koh, Katsuyoshi, Eguchi, Mariko, Ishii, Eiichi, Ohara, Osamu, Shultz, Leonard D., Mizutani, Shuki, Ishikawa, Fumihiko
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2021
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Research paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7878180/
https://ncbi.nlm.nih.gov/pubmed/33581643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2021.103235
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