Identification of CD34(+) and CD34(−) leukemia-initiating cells in MLL-rearranged human acute lymphoblastic leukemia

Translocation of the mixed-lineage leukemia (MLL) gene with AF4, AF9, or ENL results in acute leukemia with both lymphoid and myeloid involvement. We characterized leukemia-initiating cells (LICs) in primary infant MLL-rearranged leukemia using a xenotransplantation model. In MLL-AF4 patients, CD34(...

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Publicat a:Blood
Autors principals: Aoki, Yuki, Watanabe, Takashi, Saito, Yoriko, Kuroki, Yoko, Hijikata, Atsushi, Takagi, Masatoshi, Tomizawa, Daisuke, Eguchi, Mariko, Eguchi-Ishimae, Minenori, Kaneko, Akiko, Ono, Rintaro, Sato, Kaori, Suzuki, Nahoko, Fujiki, Saera, Koh, Katsuyoshi, Ishii, Eiichi, Shultz, Leonard D., Ohara, Osamu, Mizutani, Shuki, Ishikawa, Fumihiko
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2015
Matèries:
Lymphoid Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4319237/
https://ncbi.nlm.nih.gov/pubmed/25538041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-03-563304
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