Induction of WT1-specific human CD8(+) T cells from human HSCs in HLA class I Tg NOD/SCID/IL2rgKO mice

Induction of specific immune response against therapy-resistant tumor cells can potentially improve clinical outcomes in malignancies. To optimize immunotherapy in the clinic, we aimed to create an in vivo model enabling us to analyze human cytotoxic T-lymphocyte (CTL) responses against human malign...

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Dettagli Bibliografici
Pubblicato in:Blood
Autori principali: Najima, Yuho, Tomizawa-Murasawa, Mariko, Saito, Yoriko, Watanabe, Takashi, Ono, Rintaro, Ochi, Toshiki, Suzuki, Nahoko, Fujiwara, Hiroshi, Ohara, Osamu, Shultz, Leonard D., Yasukawa, Masaki, Ishikawa, Fumihiko
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2016
Soggetti:
Immunobiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4751022/
https://ncbi.nlm.nih.gov/pubmed/26702062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-10-604777
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