Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2rγ(null) humanized mice

Whereas humanized mouse models have contributed significantly to human immunology research, human T cells developing in mouse thymic environment fail to demonstrate HLA-restricted function. To achieve HLA-restricted human immune response, we created an immune-compromised non-obese diabetic/SCID/IL2r...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Shultz, Leonard D., Saito, Yoriko, Najima, Yuho, Tanaka, Satoshi, Ochi, Toshiki, Tomizawa, Mariko, Doi, Takehiko, Sone, Akiko, Suzuki, Nahoko, Fujiwara, Hiroshi, Yasukawa, Masaki, Ishikawa, Fumihiko
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2010
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919921/
https://ncbi.nlm.nih.gov/pubmed/20615947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1000475107
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg