Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2rγ(null) humanized mice

Whereas humanized mouse models have contributed significantly to human immunology research, human T cells developing in mouse thymic environment fail to demonstrate HLA-restricted function. To achieve HLA-restricted human immune response, we created an immune-compromised non-obese diabetic/SCID/IL2r...

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Detalhes bibliográficos
Main Authors: Shultz, Leonard D., Saito, Yoriko, Najima, Yuho, Tanaka, Satoshi, Ochi, Toshiki, Tomizawa, Mariko, Doi, Takehiko, Sone, Akiko, Suzuki, Nahoko, Fujiwara, Hiroshi, Yasukawa, Masaki, Ishikawa, Fumihiko
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919921/
https://ncbi.nlm.nih.gov/pubmed/20615947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1000475107
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