Development of functional human blood and immune systems in NOD/SCID/IL2 receptor γ chain(null) mice

Here we report that a new nonobese diabetic/severe combined immunodeficient (NOD/SCID) mouse line harboring a complete null mutation of the common cytokine receptor γ chain (NOD/SCID/interleukin 2 receptor [IL2r] γ(null)) efficiently supports development of functional human hemato-lymphopoiesis. Pur...

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Detalhes bibliográficos
Main Authors: Ishikawa, Fumihiko, Yasukawa, Masaki, Lyons, Bonnie, Yoshida, Shuro, Miyamoto, Toshihiro, Yoshimoto, Goichi, Watanabe, Takeshi, Akashi, Koichi, Shultz, Leonard D., Harada, Mine
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society of Hematology 2005
Assuntos:
Hematopoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895228/
https://ncbi.nlm.nih.gov/pubmed/15920010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-02-0516
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