Engraftment of human HSCs in nonirradiated newborn NOD-scid IL2rγ(null) mice is enhanced by transgenic expression of membrane-bound human SCF

Immunodeficient mice engrafted with human HSCs support multidisciplinary translational experimentation, including the study of human hematopoiesis. Heightened levels of human HSC engraftment are observed in immunodeficient mice expressing mutations in the IL2-receptor common γ chain (IL2rg) gene, in...

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Bibliographic Details
Main Authors: Brehm, Michael A., Racki, Waldemar J., Leif, Jean, Burzenski, Lisa, Hosur, Vishnu, Wetmore, Amber, Gott, Bruce, Herlihy, Mary, Ignotz, Ronald, Dunn, Raymond, Shultz, Leonard D., Greiner, Dale L.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2012
Subjects:
Hematopoiesis and Stem Cells
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3327456/
https://ncbi.nlm.nih.gov/pubmed/22246028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-05-353243
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