Targeting critical kinases and anti-apoptotic molecules overcomes steroid resistance in MLL-rearranged leukaemia

BACKGROUND: Acute lymphoblastic leukaemia with mixed lineage leukaemia gene rearrangement (MLL-ALL) frequently affects infants and is associated with a poor prognosis. Primary refractory and relapsed disease due to resistance to glucocorticoids (GCs) remains a substantial hurdle to improving clinica...

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Bibliografiske detaljer
Udgivet i:EBioMedicine
Main Authors: de Groot, Anne P., Saito, Yoriko, Kawakami, Eiryo, Hashimoto, Mari, Aoki, Yuki, Ono, Rintaro, Ogahara, Ikuko, Fujiki, Saera, Kaneko, Akiko, Sato, Kaori, Kajita, Hiroshi, Watanabe, Takashi, Takagi, Masatoshi, Tomizawa, Daisuke, Koh, Katsuyoshi, Eguchi, Mariko, Ishii, Eiichi, Ohara, Osamu, Shultz, Leonard D., Mizutani, Shuki, Ishikawa, Fumihiko
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2021
Fag:
Research paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7878180/
https://ncbi.nlm.nih.gov/pubmed/33581643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2021.103235
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