Overcoming mutational complexity in acute myeloid leukemia by inhibition of critical pathways

Numerous variant alleles are associated with human acute myeloid leukemia (AML). However, the same variants are also found in individuals with no hematological disease, making their functional relevance obscure. Through NOD.Cg-Prkdc(scid)//2rg(tmlWjl)/Sz (NSG) xenotransplantation, we functionally id...

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Pubblicato in:Sci Transl Med
Autori principali: Saito, Yoriko, Mochizuki, Yoshiki, Ogahara, Ikuko, Watanabe, Takashi, Hogdal, Leah, Takagi, Shinsuke, Sato, Kaori, Kaneko, Akiko, Kajita, Hiroshi, Uchida, Naoyuki, Fukami, Takehiro, Shultz, Leonard D., Taniguchi, Shuichi, Ohara, Osamu, Letai, Anthony G., Ishikawa, Fumihiko
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6377281/
https://ncbi.nlm.nih.gov/pubmed/29070697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aao1214
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