MLL leukemia induction by genome editing of human CD34(+) hematopoietic cells

Chromosomal rearrangements involving the mixed-lineage leukemia (MLL) gene occur in primary and treatment-related leukemias and confer a poor prognosis. Studies based primarily on mouse models have substantially advanced our understanding of MLL leukemia pathogenesis, but often use supraphysiologica...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Buechele, Corina, Breese, Erin H., Schneidawind, Dominik, Lin, Chiou-Hong, Jeong, Johan, Duque-Afonso, Jesus, Wong, Stephen H. K., Smith, Kevin S., Negrin, Robert S., Porteus, Matthew, Cleary, Michael L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2015
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4591792/
https://ncbi.nlm.nih.gov/pubmed/26311362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-05-646398
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