MLL leukemia induction by t(9;11) chromosomal translocation in human hematopoietic stem cells using genome editing

Genome editing provides a potential approach to model de novo leukemogenesis in primary human hematopoietic stem and progenitor cells (HSPCs) through induction of chromosomal translocations by targeted DNA double-strand breaks. However, very low efficiency of translocations and lack of markers for t...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Schneidawind, Corina, Jeong, Johan, Schneidawind, Dominik, Kim, In-Suk, Duque-Afonso, Jesús, Wong, Stephen Hon Kit, Iwasaki, Masayuki, Breese, Erin H., Zehnder, James L., Porteus, Matthew, Cleary, Michael L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2018
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5916000/
https://ncbi.nlm.nih.gov/pubmed/29650777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017013748
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