High-efficiency CRISPR induction of t(9;11) chromosomal translocations and acute leukemias in human blood stem cells

Chromosomal rearrangements involving the mixed lineage leukemia (MLL) gene, also known as KMT2A, are often observed in human leukemias and are generally associated with a poor prognosis. To model these leukemias, we applied clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 gene...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Blood Adv
Κύριοι συγγραφείς: Jeong, Johan, Jager, Astraea, Domizi, Pablo, Pavel-Dinu, Mara, Gojenola, Linda, Iwasaki, Masayuki, Wei, Michael C., Pan, Feng, Zehnder, James L., Porteus, Matthew H., Davis, Kara L., Cleary, Michael L.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society of Hematology 2019
Θέματα:
Lymphoid Neoplasia
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6784514/
https://ncbi.nlm.nih.gov/pubmed/31582391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019000450
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