High-efficiency CRISPR induction of t(9;11) chromosomal translocations and acute leukemias in human blood stem cells

Chromosomal rearrangements involving the mixed lineage leukemia (MLL) gene, also known as KMT2A, are often observed in human leukemias and are generally associated with a poor prognosis. To model these leukemias, we applied clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 gene...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Jeong, Johan, Jager, Astraea, Domizi, Pablo, Pavel-Dinu, Mara, Gojenola, Linda, Iwasaki, Masayuki, Wei, Michael C., Pan, Feng, Zehnder, James L., Porteus, Matthew H., Davis, Kara L., Cleary, Michael L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2019
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6784514/
https://ncbi.nlm.nih.gov/pubmed/31582391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019000450
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