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The tyrosine kinase v‐Src modifies cytotoxicities of anticancer drugs targeting cell division

v‐Src oncogene causes cell transformation through its strong tyrosine kinase activity. We have revealed that v‐Src‐mediated cell transformation occurs at a low frequency and it is attributed to mitotic abnormalities‐mediated chromosome instability. v‐Src directly phosphorylates Tyr‐15 of cyclin‐depe...

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Bibliografiske detaljer
Udgivet i:J Cell Mol Med
Main Authors: Yuki, Ryuzaburo, Hagino, Mari, Ueno, Sachi, Kuga, Takahisa, Saito, Youhei, Fukumoto, Yasunori, Yamaguchi, Noritaka, Yamaguchi, Naoto, Nakayama, Yuji
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7875926/
https://ncbi.nlm.nih.gov/pubmed/33465289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.16270
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