The tyrosine kinase v-Src causes mitotic slippage by phosphorylating an inhibitory tyrosine residue of Cdk1

The nonreceptor tyrosine kinase v-Src is an oncogene first identified in Rous sarcoma virus. The oncogenic effects of v-Src have been intensively studied; however, its effects on chromosomal integrity are not fully understood. Here, using HeLa S3/v-Src cells having inducible v-Src expression, we fou...

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Pubblicato in:J Biol Chem
Autori principali: Horiuchi, Maria, Kuga, Takahisa, Saito, Youhei, Nagano, Maiko, Adachi, Jun, Tomonaga, Takeshi, Yamaguchi, Naoto, Nakayama, Yuji
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2018
Soggetti:
Cell Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6177586/
https://ncbi.nlm.nih.gov/pubmed/30135207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002784
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