Combination Treatment of OSI-906 with Aurora B Inhibitor Reduces Cell Viability via Cyclin B1 Degradation-Induced Mitotic Slippage

Insulin-like growth factor 1 receptor (IGF1R), a receptor-type tyrosine kinase, transduces signals related to cell proliferation, survival, and differentiation. We recently reported that OSI-906, an IGF1R inhibitor, in combination with the Aurora B inhibitor ZM447439 suppresses cell proliferation. H...

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Bibliographic Details
Published in:Int J Mol Sci
Main Authors: Ikeda, Yuki, Yasutake, Ryuji, Yuki, Ryuzaburo, Saito, Youhei, Nakayama, Yuji
Format: Artigo
Language:Inglês
Published: MDPI 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8197973/
https://ncbi.nlm.nih.gov/pubmed/34071893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22115706
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