Mitotic slippage and the subsequent cell fates after inhibition of Aurora B during tubulin-binding agent–induced mitotic arrest

Tubulin-binding agents (TBAs) are designed to target microtubule (MT) dynamics, resulting in compromised mitotic spindles and an unsatisfied spindle assembly checkpoint. The activity of Aurora B kinase is indispensable for TBA-induced mitotic arrest, and its inhibition causes mitotic slippage and po...

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Publicado no:Sci Rep
Main Authors: Tsuda, Yasuo, Iimori, Makoto, Nakashima, Yuichiro, Nakanishi, Ryota, Ando, Koji, Ohgaki, Kippei, Kitao, Hiroyuki, Saeki, Hiroshi, Oki, Eiji, Maehara, Yoshihiko
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5711930/
https://ncbi.nlm.nih.gov/pubmed/29196757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-17002-z
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