Liquid chromatography-tandem mass spectrometry analysis of oxidation of 2′-, 3′-, 4′-, and 6-hydroxyflavanones by human cytochrome P450 enzymes

1. 2′-Hydroxyflavanone (2′OHFva), 3′OHFva, 4′OHFva, and 6OHFva, the major oxidative products of flavanone by human cytochrome P450 (P450, CYP) enzymes, were studied in regard to further oxidation by human CYP1A1, 1A2, 1B1.1, 1B1.3, and 2A6. The products formed were analyzed with LC-MS/MS and charact...

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Publicado en:Xenobiotica
Autores principales: Shimada, Tsutomu, Nagayoshi, Haruna, Murayama, Norie, Takenaka, Shigeo, Katahira, Jun, Kim, Vitchan, Kim, Donghak, Komori, Masayuki, Yamazaki, Hiroshi, Guengerich, F. Peter
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7875482/
https://ncbi.nlm.nih.gov/pubmed/33047997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/00498254.2020.1836433
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