Genome-wide Screens Identify Lineage- and Tumor-Specific Genes Modulating MHC-I- and MHC-II-Restricted Immunosurveillance of Human Lymphomas

Tumors frequently subvert MHC class I (MHC-I) peptide presentation to evade CD8(+) T cell immunosurveillance, though how this is accomplished is not always well-defined. To identify the global regulatory networks controlling antigen presentation, we employed genome-wide screening in human diffuse la...

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Publicado no:Immunity
Main Authors: Dersh, Devin, Phelan, James D., Gumina, Megan E., Wang, Boya, Arbuckle, Jesse H., Holly, Jaroslav, Kishton, Rigel J., Markowitz, Tovah E., Seedhom, Mina O., Fridlyand, Nathan, Wright, George W., Huang, Da Wei, Ceribelli, Michele, Thomas, Craig J., Lack, Justin B., Restifo, Nicholas P., Kristie, Thomas M., Staudt, Louis M., Yewdell, Jonathan W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7874576/
https://ncbi.nlm.nih.gov/pubmed/33271120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2020.11.002
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