Ribosomal Proteins Regulate MHC Class I Peptide Generation for Immunosurveillance

The MHC class I antigen presentation system enables T cell immunosurveillance of cancers and viruses. A substantial fraction of the immunopeptidome derives from rapidly degraded nascent polypeptides (DRiPs). By knocking down each of the 80 ribosomal proteins, we identified proteins that modulate pep...

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Publicado no:Mol Cell
Main Authors: Wei, Jiajie, Kishton, Rigel J., Angel, Matthew, Conn, Crystal S., Dalla-Venezia, Nicole, Marcel, Virginie, Vincent, Anne, Catez, Frédéric, Ferré, Sabrina, Ayadi, Lilia, Marchand, Virginie, Dersh, Devin, Gibbs, James S., Ivanov, Ivaylo P., Fridlyand, Nathan, Couté, Yohann, Diaz, Jean-Jacques, Qian, Shu-Bing, Staudt, Louis M., Restifo, Nicholas P., Yewdell, Jonathan W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6697054/
https://ncbi.nlm.nih.gov/pubmed/30712990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.12.020
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