The in situ structure of Parkinson’s disease-linked LRRK2

Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most frequent cause of familial Parkinson’s disease. LRRK2 is a multi-domain protein containing a kinase and GTPase. Using correlative light and electron microscopy, in situ cryo-electron tomography and subtomogram analysis, we reveal a 14-Å...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Watanabe, Reika, Buschauer, Robert, Böhning, Jan, Audagnotto, Martina, Lasker, Keren, Lu, Tsan-Wen, Boassa, Daniela, Taylor, Susan, Villa, Elizabeth
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7869717/
https://ncbi.nlm.nih.gov/pubmed/32783917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.08.004
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