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Structure of LRRK2 in Parkinson’s disease and model for microtubule interaction
Leucine Rich Repeat Kinase 2 (LRRK2) is the most commonly mutated gene in familial Parkinson’s disease (PD)(1) and is also linked to its idiopathic form(2). LRRK2 is proposed to function in membrane trafficking(3) and co-localizes with microtubules(4). Despite LRRK2’s fundamental importance for unde...
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| Veröffentlicht in: | Nature |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7726071/ https://ncbi.nlm.nih.gov/pubmed/32814344 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2673-2 |
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