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The in situ structure of Parkinson’s disease-linked LRRK2
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most frequent cause of familial Parkinson’s disease. LRRK2 is a multi-domain protein containing a kinase and GTPase. Using correlative light and electron microscopy, in situ cryo-electron tomography and subtomogram analysis, we reveal a 14-Å...
Tallennettuna:
| Julkaisussa: | Cell |
|---|---|
| Päätekijät: | , , , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2020
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7869717/ https://ncbi.nlm.nih.gov/pubmed/32783917 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.08.004 |
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