Structure of LRRK2 in Parkinson’s disease and model for microtubule interaction

Leucine Rich Repeat Kinase 2 (LRRK2) is the most commonly mutated gene in familial Parkinson’s disease (PD)(1) and is also linked to its idiopathic form(2). LRRK2 is proposed to function in membrane trafficking(3) and co-localizes with microtubules(4). Despite LRRK2’s fundamental importance for unde...

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Vydáno v:Nature
Hlavní autoři: Deniston, CK, Salogiannis, J, Mathea, S, Snead, DM, Lahiri, I, Matyszewski, M, Donosa, O, Watanabe, R, Böhning, J, Shiau, AK, Knapp, S, Villa, E, Reck-Peterson, SL, Leschziner, AE
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7726071/
https://ncbi.nlm.nih.gov/pubmed/32814344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2673-2
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