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Lis1 Acts as a “Clutch” between the ATPase and Microtubule-Binding Domains of the Dynein Motor
The lissencephaly protein Lis1 has been reported to regulate the mechanical behavior of cytoplasmic dynein, the primary minus-end-directed microtubule motor. However, the regulatory mechanism remains poorly understood. Here, we address this issue using purified proteins from Saccharomyces cerevisiae...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Cell Press
2012
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3438448/ https://ncbi.nlm.nih.gov/pubmed/22939623 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.07.022 |
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