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Cryo-electron tomography reveals the microtubule-bound form of inactive LRRK2

Parkinson’s disease (PD) is the second most common neurodegenerative disorder. Mutations in human leucine-rich repeat kinase 2 (LRRK2), a multi-domain protein containing both a kinase and a GTPase, are a leading cause of the familial form of PD. Pathogenic LRRK2 mutations increase LRRK2 kinase activ...

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Principais autores: Siyu Chen, Tamar Basiashvili, Joshua Hutchings, Marta Sanz Murillo, Amalia Villagran Suarez, Erica Xiong, Jaime Alegrio Louro, Andres E Leschziner, Elizabeth Villa
פורמט: Artigo
שפה:Inglês
יצא לאור: eLife Sciences Publications Ltd 2025-10-01
סדרה:eLife
נושאים:
LRRK2
microtubules
parkinson's disease
גישה מקוונת:https://elifesciences.org/articles/100799
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