Cryo-electron tomography reveals the microtubule-bound form of inactive LRRK2

Parkinson’s disease (PD) is the second most common neurodegenerative disorder. Mutations in human leucine-rich repeat kinase 2 (LRRK2), a multi-domain protein containing both a kinase and a GTPase, are a leading cause of the familial form of PD. Pathogenic LRRK2 mutations increase LRRK2 kinase activ...

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Principais autores:	Siyu Chen, Tamar Basiashvili, Joshua Hutchings, Marta Sanz Murillo, Amalia Villagran Suarez, Erica Xiong, Jaime Alegrio Louro, Andres E Leschziner, Elizabeth Villa
Format:	Artigo
Jezik:	Inglês
Izdano:	eLife Sciences Publications Ltd 2025-10-01
Serija:	eLife
Teme:	LRRK2 microtubules parkinson's disease
Online dostop:	https://elifesciences.org/articles/100799
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