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Zeroing in on LRRK2-Linked Pathogenic Mechanisms in Parkinson’s Disease
The frequency and potency of mutations in the LRRK2 gene redefine the role of genetic susceptibility in Parkinson’s disease. Dominant missense mutations that fulfill initial criteria for potential gain of function mechanisms coupled with enzymatic activity likely amenable to small molecule inhibitio...
में बचाया:
| मुख्य लेखकों: | , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2008
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2745057/ https://ncbi.nlm.nih.gov/pubmed/18973807 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2008.09.015 |
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