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Zeroing in on LRRK2-Linked Pathogenic Mechanisms in Parkinson’s Disease
The frequency and potency of mutations in the LRRK2 gene redefine the role of genetic susceptibility in Parkinson’s disease. Dominant missense mutations that fulfill initial criteria for potential gain of function mechanisms coupled with enzymatic activity likely amenable to small molecule inhibitio...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2745057/ https://ncbi.nlm.nih.gov/pubmed/18973807 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2008.09.015 |
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