NOTCH Activation via gp130/STAT3 Signaling Confers Resistance to Chemoradiotherapy

SIMPLE SUMMARY: Resistance to chemoradiotherapy represents a fundamental problem in modern oncology because it exposes patients to the potential negative side-effects of both radiation and chemotherapy without any clinical benefit. This study uncovers that the inflammatory signaling hub STAT3 conspi...

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Udgivet i:Cancers (Basel)
Main Authors: Koerdel, Kristin, Spitzner, Melanie, Meyer, Thomas, Engels, Niklas, Krause, Florian, Gaedcke, Jochen, Conradi, Lena-Christin, Haubrock, Martin, Beißbarth, Tim, Leha, Andreas, Johnsen, Steven A., Ghadimi, B. Michael, Rose-John, Stefan, Grade, Marian, Wienands, Jürgen
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7865718/
https://ncbi.nlm.nih.gov/pubmed/33530306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13030455
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