Targeting oncoproteins with a positive selection assay for protein degraders

Most intracellular proteins lack hydrophobic pockets suitable for altering their function with drug-like small molecules. Recent studies indicate that some undruggable proteins can be targeted by compounds that can degrade them. For example, thalidomide-like drugs (IMiDs) degrade the critical multip...

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書誌詳細
出版年:Sci Adv
主要な著者: Koduri, Vidyasagar, Duplaquet, Leslie, Lampson, Benjamin L., Wang, Adam C., Sabet, Amin H., Ishoey, Mette, Paulk, Joshiawa, Teng, Mingxing, Harris, Isaac S., Endress, Jennifer E., Liu, Xiaoxi, Dasilva, Ethan, Paulo, Joao A., Briggs, Kimberly J., Doench, John G., Ott, Christopher J., Zhang, Tinghu, Donovan, Katherine A., Fischer, Eric S., Gygi, Steven P., Gray, Nathanael S., Bradner, James, Medin, Jeffrey A., Buhrlage, Sara J., Oser, Matthew G., Kaelin, William G.
フォーマット: Artigo
言語:Inglês
出版事項: American Association for the Advancement of Science 2021
主題:
Research Articles
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7864573/
https://ncbi.nlm.nih.gov/pubmed/33547076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abd6263
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