Targeting oncoproteins with a positive selection assay for protein degraders

Most intracellular proteins lack hydrophobic pockets suitable for altering their function with drug-like small molecules. Recent studies indicate that some undruggable proteins can be targeted by compounds that can degrade them. For example, thalidomide-like drugs (IMiDs) degrade the critical multip...

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Argitaratua izan da:Sci Adv
Egile Nagusiak: Koduri, Vidyasagar, Duplaquet, Leslie, Lampson, Benjamin L., Wang, Adam C., Sabet, Amin H., Ishoey, Mette, Paulk, Joshiawa, Teng, Mingxing, Harris, Isaac S., Endress, Jennifer E., Liu, Xiaoxi, Dasilva, Ethan, Paulo, Joao A., Briggs, Kimberly J., Doench, John G., Ott, Christopher J., Zhang, Tinghu, Donovan, Katherine A., Fischer, Eric S., Gygi, Steven P., Gray, Nathanael S., Bradner, James, Medin, Jeffrey A., Buhrlage, Sara J., Oser, Matthew G., Kaelin, William G.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Association for the Advancement of Science 2021
Gaiak:
Research Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7864573/
https://ncbi.nlm.nih.gov/pubmed/33547076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abd6263
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