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Developing irreversible inhibitors of the protein kinase cysteinome
Protein kinases are a large family of approximately 530 highly conserved enzymes that transfer a γ-phosphate group from ATP to a variety of amino acid residues such as tyrosine, serine and threonine which serves as a ubiquitous mechanism for cellular signal transduction. The clinical success of a nu...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3583020/ https://ncbi.nlm.nih.gov/pubmed/23438744 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2012.12.006 |
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