Clinical stage EGFR inhibitors irreversibly alkylate Bmx Kinase

Irreversible HER/erbB inhibitors selectively inhibit HER-family kinases by targeting a unique cysteine residue located within the ATP-binding pocket. Sequence alignment reveals that this rare cysteine is also present in ten other protein kinases including all five Tec-family members. We demonstrate...

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Hlavní autoři: Hur, Wooyoung, Velentza, Anastasia, Kim, Sungjoon, Flatauer, Laura, Jiang, Xinnong, Valente, David, Mason, Daniel E, Suzuki, Melissa, Larson, Brad, Zhang, Jianming, Zagorska, Anna, DiDonato, Michael, Nagle, Advait, Warmuth, Markus, Balk, Steven P, Peters, Eric C, Gray, Nathanael S
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2610413/
https://ncbi.nlm.nih.gov/pubmed/18667312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.07.062
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