Clinical stage EGFR inhibitors irreversibly alkylate Bmx Kinase

Irreversible HER/erbB inhibitors selectively inhibit HER-family kinases by targeting a unique cysteine residue located within the ATP-binding pocket. Sequence alignment reveals that this rare cysteine is also present in ten other protein kinases including all five Tec-family members. We demonstrate...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Hur, Wooyoung, Velentza, Anastasia, Kim, Sungjoon, Flatauer, Laura, Jiang, Xinnong, Valente, David, Mason, Daniel E, Suzuki, Melissa, Larson, Brad, Zhang, Jianming, Zagorska, Anna, DiDonato, Michael, Nagle, Advait, Warmuth, Markus, Balk, Steven P, Peters, Eric C, Gray, Nathanael S
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2610413/
https://ncbi.nlm.nih.gov/pubmed/18667312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.07.062
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados