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Exploration of Type II Binding Mode: A Privileged Approach for Kinase Inhibitor Focused Drug Discovery?
[Image: see text] The ATP site of kinases displays remarkable conformational flexibility when accommodating chemically diverse small molecule inhibitors. The so-called activation segment, whose conformation controls catalytic activity and access to the substrate binding pocket, can undergo a large c...
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| Glavni autori: | , , , , , , |
|---|---|
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Chemical
Society
2014
|
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4068218/ https://ncbi.nlm.nih.gov/pubmed/24730530 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb500129t |
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