Effects of chronic hyperinsulinemia on metabolic pathways and insulin signaling in the fetal liver

The effect of chronic of hyperinsulinemia in the fetal liver is poorly understood. Here, we produced hyperinsulinemia with euglycemia for ∼8 days in fetal sheep [hyperinsulinemic (INS)] at 0.9 gestation. INS fetuses had increased insulin and decreased oxygen and amino acid (AA) concentrations compar...

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Detalhes bibliográficos
Publicado no:Am J Physiol Endocrinol Metab
Principais autores: Rozance, Paul J., Jones, Amanda K., Bourque, Stephanie L., D’Alessandro, Angelo, Hay, William. W., Brown, Laura D., Wesolowski, Stephanie R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7864241/
https://ncbi.nlm.nih.gov/pubmed/32830555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00323.2020
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