A Chronic Fetal Leucine Infusion Potentiates Fetal Insulin Secretion and Increases Pancreatic Islet Size, Vascularity, and β Cells in Late-Gestation Sheep

BACKGROUND: Infusion of a complete amino acid mixture into normal late-gestation fetal sheep potentiates glucose-stimulated insulin secretion (GSIS). Leucine acutely stimulates insulin secretion in late-gestation fetal sheep and isolated fetal sheep islets in vitro. OBJECTIVES: We hypothesized that...

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Publicado en:J Nutr
Autores principales: Boehmer, Brit H, Brown, Laura D, Wesolowski, Stephanie R, Hay, William W, Rozance, Paul J
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2020
Materias:
Nutrient Physiology, Metabolism, and Nutrient-Nutrient Interactions
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7398779/
https://ncbi.nlm.nih.gov/pubmed/32470982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jn/nxaa138
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