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Using the Cancer Dependency Map to Identify the Mechanism of Action of a Cytotoxic Alkenyl Derivative from the Fruit of Choerospondias axillaris

An extract prepared from the fruit of Choerospondias axillaris exhibited differential cytotoxic effects when tested in a panel of pediatric cancer cell lines [Ewing sarcoma (A-673), rhabdomyosarcoma (SJCRH30), medulloblastoma (D283), and hepatoblastoma (Hep293TT)]. Bioassay-guided fractionation led...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Nat Prod
Päätekijät: Kil, Yun-Seo, Risinger, April L., Petersen, Cora L., Liang, Huiyun, Grkovic, Tanja, O’Keefe, Barry R., Mooberry, Susan L., Cichewicz, Robert H.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2020
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7864215/
https://ncbi.nlm.nih.gov/pubmed/32105068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jnatprod.9b00896
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