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Anacolosins A–F and Corymbulosins X and Y, Clerodane Diterpenes from Anacolosa clarkii Exhibiting Cytotoxicity toward Pediatric Cancer Cell Lines

An extract of the plant Anacolosa clarkii was obtained from the NCI Natural Products Repository, and it showed cytotoxic activity toward several types of pediatric solid tumor cell lines. Bioassay-guided fractionation led to the purification of eight new clerodane diterpenes [anacolosins A–F (1–6) a...

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Detalhes bibliográficos
Publicado no:J Nat Prod
Main Authors: Cai, Shengxin, Risinger, April L., Petersen, Cora L., Grkovic, Tanja, O’Keefe, Barry R., Mooberry, Susan L., Cichewicz, Robert H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8202969/
https://ncbi.nlm.nih.gov/pubmed/30830773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jnatprod.8b01015
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