CRISPR-Cas9 Genome-wide Knockout Screen Identifies Mechanism of Selective Activity of Dehydrofalcarinol in Mesenchymal Stem-like Triple-Negative Breast Cancer Cells

There are no targeted therapies available for triple-negative breast cancers (TNBCs) in part because they represent a heterogeneous group of tumors with diverse oncogenic drivers. Our goal is to identify targeted therapies for subtypes of these cancers using a mechanism-blind screen of natural produ...

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Vydáno v:J Nat Prod
Hlavní autoři: Grant, Corena V., Cai, Shengxin, Risinger, April L., Liang, Huiyun, O’Keefe, Barry R., Doench, John G., Cichewicz, Robert H., Mooberry, Susan L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7722265/
https://ncbi.nlm.nih.gov/pubmed/33021790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jnatprod.0c00642
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