A novel UBE2T inhibitor suppresses Wnt/β-catenin signaling hyperactivation and gastric cancer progression by blocking RACK1 ubiquitination

Dysregulation of the Wnt/β-catenin signaling pathway is critically involved in gastric cancer (GC) progression. However, current Wnt pathway inhibitors being studied in preclinical or clinical settings for other cancers such as colorectal and pancreatic cancers are either too cytotoxic or insufficie...

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Publicat a:Oncogene
Autors principals: Yu, Zeyuan, Jiang, Xiangyan, Qin, Long, Deng, Haixiao, Wang, Jianli, Ren, Wen, Li, Hongbin, Zhao, Lei, Liu, Huanxiang, Yan, Hong, Shi, Wengui, Wang, Qi, Luo, Changjiang, Long, Bo, Zhou, Huinian, Sun, Hui, Jiao, Zuoyi
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7862066/
https://ncbi.nlm.nih.gov/pubmed/33323973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-01572-w
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