A novel UBE2T inhibitor suppresses Wnt/β-catenin signaling hyperactivation and gastric cancer progression by blocking RACK1 ubiquitination

Dysregulation of the Wnt/β-catenin signaling pathway is critically involved in gastric cancer (GC) progression. However, current Wnt pathway inhibitors being studied in preclinical or clinical settings for other cancers such as colorectal and pancreatic cancers are either too cytotoxic or insufficie...

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Veröffentlicht in:Oncogene
Hauptverfasser: Yu, Zeyuan, Jiang, Xiangyan, Qin, Long, Deng, Haixiao, Wang, Jianli, Ren, Wen, Li, Hongbin, Zhao, Lei, Liu, Huanxiang, Yan, Hong, Shi, Wengui, Wang, Qi, Luo, Changjiang, Long, Bo, Zhou, Huinian, Sun, Hui, Jiao, Zuoyi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7862066/
https://ncbi.nlm.nih.gov/pubmed/33323973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-01572-w
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