Hyperactivation of HER2-SHCBP1-PLK1 axis promotes tumor cell mitosis and impairs trastuzumab sensitivity to gastric cancer

Trastuzumab is the backbone of HER2-directed gastric cancer therapy, but poor patient response due to insufficient cell sensitivity and drug resistance remains a clinical challenge. Here, we report that HER2 is involved in cell mitotic promotion for tumorigenesis by hyperactivating a crucial HER2-SH...

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書誌詳細
出版年:Nat Commun
主要な著者: Shi, Wengui, Zhang, Gengyuan, Ma, Zhijian, Li, Lianshun, Liu, Miaomiao, Qin, Long, Yu, Zeyuan, Zhao, Lei, Liu, Yang, Zhang, Xue, Qin, Junjie, Ye, Huili, Jiang, Xiangyan, Zhou, Huinian, Sun, Hui, Jiao, Zuoyi
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group UK 2021
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC8121856/
https://ncbi.nlm.nih.gov/pubmed/33990570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23053-8
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