BAP1 mutant uveal melanoma is stratified by metabolic phenotypes with distinct vulnerability to metabolic inhibitors

Cancer cell metabolism is a targetable vulnerability; however, a precise understanding of metabolic heterogeneity is required. Inactivating mutations in BRCA1-associated protein 1 (BAP1) are associated with metastasis in uveal melanoma (UM), the deadliest adult eye cancer. BAP1 functions in UM remai...

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Bibliographic Details
Published in:Oncogene
Main Authors: Han, Anna, Purwin, Timothy J., Bechtel, Nelisa, Liao, Connie, Chua, Vivian, Seifert, Erin, Sato, Takami, Schug, Zachary T., Speicher, David W., Harbour, J. William, Aplin, Andrew E.
Format: Artigo
Language:Inglês
Published: 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7856044/
https://ncbi.nlm.nih.gov/pubmed/33208912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-01554-y
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