Co-targeting HGF-cMET signaling with MEK inhibitors in metastatic uveal melanoma

Metastatic uveal melanoma (UM) patients usually die within one year of diagnosis, emphasizing an urgent need to develop new treatment strategies. The liver is the most common site of metastasis. Mitogen-activated protein kinase kinase (MEK) inhibitors improve survival in V600 BRAF-mutated cutaneous...

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Bibliografiset tiedot
Julkaisussa:Mol Cancer Ther
Päätekijät: Cheng, Hanyin, Chua, Vivian, Liao, Connie, Purwin, Timothy J., Terai, Mizue, Kageyama, Ken, Davies, Michael A., Sato, Takami, Aplin, Andrew E.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2017
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5337170/
https://ncbi.nlm.nih.gov/pubmed/28138035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-16-0552
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